The DEFA3 Polyclonal Antibody (CAB5340) is a valuable tool for researchers studying the DEFA3 protein, a member of the defensin alpha family involved in innate immunity and host defense. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the DEFA3 protein, researchers can accurately detect and analyze its expression in various cell types, making it an essential asset for studies in immunology, infectious diseases, and inflammatory conditions.
DEFA3 plays a crucial role in the first line of defense against microbial infections by promoting the destruction of pathogenic invaders through its antimicrobial properties. Its involvement in immune responses and regulation makes it a promising target for research into conditions such as inflammatory bowel disease, cystic fibrosis, and sepsis. Understanding the function and regulation of DEFA3 is essential for developing novel therapeutic strategies aimed at enhancing immune defense mechanisms in these pathological contexts.
Product Name:
DEFA3 Rabbit Polyclonal Antibody
SKU:
CAB5340
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-94 of human DEFA3 (NP_005208.1).
Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 3, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 1 by only one amino acid. This gene and the gene encoding defensin, alpha 1 are both subject to copy number variation.
Purification Method:
Affinity purification
Gene ID:
1668
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using DEFA3 antibody (CAB5340) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
