The Decorin Polyclonal Antibody (CAB1669) is a valuable tool for researchers studying Decorin, a proteoglycan that plays a crucial role in extracellular matrix organization and cell signaling. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. Its ability to bind to Decorin enables precise detection and analysis in a variety of cell types, making it an ideal choice for research in areas such as tissue development, wound healing, and cancer biology.Decorin is known for its role in shaping the extracellular matrix and regulating cell behavior through interactions with growth factors and cell surface receptors.
Its dysregulation has been linked to various diseases, including cancer, fibrosis, and cardiovascular disorders. By using the Decorin Polyclonal Antibody, researchers can further explore the molecular mechanisms underlying Decorin's functions and potential therapeutic implications in these disease contexts.Investigating the function of Decorin with this antibody can provide valuable insights into its involvement in tissue remodeling, angiogenesis, and immune response modulation. Understanding the complex biology of Decorin is essential for developing targeted therapies that leverage its regulatory roles in disease processes.
Product Name:
Decorin Rabbit Polyclonal Antibody
SKU:
CAB1669
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 31-359 of Decorin (NP_001911.1).
This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients.
Purification Method:
Affinity purification
Gene ID:
1634
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.09% Sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from HeLa cells, using Decorin Rabbit pAb (CAB1669) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
