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DEAF1 Antibody (PACO55458)

SKU:
PACO55458
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$407
Frequently bought together:

Description

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DEAF1 Antibody (PACO55458)

The DEAF1 Polyclonal Antibody (PAC055458) is a valuable tool for researchers studying the DEAF1 protein, which plays a key role in transcriptional regulation and gene expression. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in various applications, including Western blotting. By targeting the DEAF1 protein, this antibody allows for the detection and analysis of DEAF1 in different cell types, making it ideal for studies in molecular biology and disease research.DEAF1 is a transcriptional repressor that is involved in gene expression regulation and has been implicated in various diseases, including cancer and neurological disorders.

Understanding the function and regulation of DEAF1 is important for gaining insights into its role in these diseases and potentially identifying new therapeutic targets. The DEAF1 Polyclonal Antibody provides researchers with a reliable tool for investigating the biological functions of DEAF1 and its potential implications in disease pathogenesis.

Antibody Name:DEAF1 Antibody (PACO55458)
Antibody SKU:PACO55458
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:ELISA:1:2000-1:10000, WB:1:500-1:5000
Species Reactivity:Human
Immunogen:Recombinant Human Deformed epidermal autoregulatory factor 1 homolog protein (73-200AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern Blot. Positive WB detected in: SH-SY5Y whole cell lysate. All lanes: DEAF1 antibody at 3.2µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 60, 59, 53, 52 kDa. Observed band size: 60 kDa.
Background:Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid, response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase. Required for neural tube closure and skeletal patterning. Regulates epithelial cell proliferation and side-branching in the mammary gland. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Isoform 1 displays greater transcriptional activity than isoform 4. Isoform 4 may inhibit transcriptional activity of isoform 1 by interacting with isoform 1 and retaining it in the cytoplasm. Transcriptional activator of EIF4G3.
Synonyms:Deformed epidermal autoregulatory factor 1 homolog (Nuclear DEAF-1-related transcriptional regulator) (NUDR) (Suppressin) (Zinc finger MYND domain-containing protein 5), DEAF1, SPN ZMYND5
UniProt Protein Function:DEAF1: a transcription factor that binds to its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE). Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase.Protein type: Transcription, coactivator/corepressor; Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 11p15.5Cellular Component: cytoplasm; nucleolus; nucleoplasm; nucleusMolecular Function: protein binding; transcription factor activityBiological Process: anatomical structure morphogenesis; embryonic skeletal development; germ cell development; negative regulation of transcription, DNA-dependent; neural tube closure; positive regulation of transcription, DNA-dependent; regulation of mammary gland epithelial cell proliferation; regulation of transcription from RNA polymerase II promoterDisease: Mental Retardation, Autosomal Dominant 24
UniProt Protein Details:
NCBI Summary:This gene encodes a zinc finger domain-containing protein that functions as a regulator of transcription. The encoded proteins binds to its own promoter as well as to that of several target genes. Activity of this protein is important in the regulation of embryonic development. Mutations in this gene have been found in individuals with autosomal dominant mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
UniProt Code:O75398
NCBI GenInfo Identifier:22256747
NCBI Gene ID:10522
NCBI Accession:O75398.1
UniProt Secondary Accession:O75398,O15152, O75399, O75510, O75511, O75512, O75513 Q9UET1, A8K1F8, A8K5R8
UniProt Related Accession:O75398
Molecular Weight:51,277 Da
NCBI Full Name:Deformed epidermal autoregulatory factor 1 homolog
NCBI Synonym Full Names:DEAF1, transcription factor
NCBI Official Symbol:DEAF1  
NCBI Official Synonym Symbols:SPN; NUDR; MRD24; ZMYND5  
NCBI Protein Information:deformed epidermal autoregulatory factor 1 homolog
UniProt Protein Name:Deformed epidermal autoregulatory factor 1 homolog
UniProt Synonym Protein Names:Nuclear DEAF-1-related transcriptional regulator; NUDR; Suppressin; Zinc finger MYND domain-containing protein 5
Protein Family:Deformed epidermal autoregulatory factor
UniProt Gene Name:DEAF1  
UniProt Entry Name:DEAF1_HUMAN
Antibodies
DEAF1 Antibody (PACO08799)
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
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