The DEAF1 Polyclonal Antibody (PACO08799) is a valuable tool for researchers studying the DEAF1 protein, a transcription factor involved in gene regulation and immune response. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the DEAF1 protein, researchers can accurately detect and analyze its expression in various cell types, making it a crucial tool for studies in immunology and cancer research.
DEAF1, also known as Deformed epidermal autoregulatory factor 1, is a key player in regulating gene expression and immune response pathways. Its role in modulating immune function makes it a promising target for investigating diseases such as cancer, autoimmune disorders, and inflammatory conditions. By uncovering the mechanisms by which DEAF1 influences immune responses, researchers can pave the way for developing novel therapeutic strategies for these diseases.
DEAF1: a transcription factor that binds to its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE). Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase.Protein type: Transcription, coactivator/corepressor; Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 11p15.5Cellular Component: cytoplasm; nucleolus; nucleoplasm; nucleusMolecular Function: protein binding; transcription factor activityBiological Process: anatomical structure morphogenesis; embryonic skeletal development; germ cell development; negative regulation of transcription, DNA-dependent; neural tube closure; positive regulation of transcription, DNA-dependent; regulation of mammary gland epithelial cell proliferation; regulation of transcription from RNA polymerase II promoterDisease: Mental Retardation, Autosomal Dominant 24
UniProt Protein Details:
NCBI Summary:
This gene encodes a zinc finger domain-containing protein that functions as a regulator of transcription. The encoded proteins binds to its own promoter as well as to that of several target genes. Activity of this protein is important in the regulation of embryonic development. Mutations in this gene have been found in individuals with autosomal dominant mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
