The DDX58 Polyclonal Antibody (CAB13407) is a valuable tool for researchers studying the DDX58 protein, also known as RIG-I. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. It binds to the DDX58 protein, allowing for accurate detection and analysis in a variety of cell types.DDX58 is a crucial component of the innate immune system, playing a key role in detecting viral RNA and triggering an antiviral immune response. Its involvement in antiviral signaling pathways makes it a promising target for research in virology and immunology.
Understanding the function and regulation of DDX58 is essential for developing strategies to combat viral infections and develop new antiviral therapies.Overall, the DDX58 Polyclonal Antibody is a reliable tool for investigating the role of the DDX58 protein in innate immunity and antiviral defense mechanisms. Its high specificity and sensitivity make it an ideal choice for researchers looking to further their understanding of these critical biological processes.
Product Name:
RIG-I/DDX58 Rabbit Polyclonal Antibody
SKU:
CAB13407
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 726-925 of human Rig-I/DDX58 (NP_055129.2).
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the regulation of the antiviral innate immune response. Mutations in this gene are associated with Singleton-Merten syndrome 2.
Purification Method:
Affinity purification
Gene ID:
23586
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Rig-I/DDX58 antibody (CAB13407) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
