The DDX54 Polyclonal Antibody (PACO00695) is a valuable tool for researchers studying DDX54, a protein involved in RNA metabolism and RNA helicase activity. This antibody is raised in rabbits and exhibits high reactivity with human samples, making it suitable for Western blot applications. By specifically targeting the DDX54 protein, this antibody enables the detection and analysis of DDX54 in various cell types, facilitating research in molecular biology and RNA processing.DDX54 is a crucial player in RNA metabolism, serving as an essential component in processes such as RNA splicing, translation, and degradation. Its involvement in RNA helicase activity suggests a role in unwinding RNA structures, influencing gene expression and protein production.
Research on DDX54 is significant in understanding gene regulation, RNA processing defects, and potential therapeutic targets for diseases like cancer and neurological disorders.By utilizing the DDX54 Polyclonal Antibody, researchers can delve into the intricate mechanisms of RNA metabolism and uncover new insights into the role of DDX54 in cellular processes. This antibody serves as a valuable tool in unraveling the complexities of gene expression and RNA biology, offering opportunities for advancements in biomedical research and drug development.
Antibody Name:
DDX54 Antibody
Antibody SKU:
PACO00695
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human DDX54.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
DDX54; ATP-dependent RNA helicase DDX54; ATP-dependent RNA helicase DP97; DEAD box RNA helicase 97 kDa; DEAD box protein 54
UniProt Protein Function:
DDX54: Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors. Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.6.4.13; Helicase; Transcription, coactivator/corepressor; Nucleolus; RNA processing; Nuclear receptor co-regulatorChromosomal Location of Human Ortholog: 12q24.13Cellular Component: membrane; nucleolus; nucleusMolecular Function: estrogen receptor binding; transcription corepressor activity; ATP-dependent RNA helicase activity; ATP binding; receptor bindingBiological Process: RNA processing; estrogen receptor signaling pathway; transcription, DNA-dependent; regulation of transcription, DNA-dependent; RNA metabolic process
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The nucleolar protein encoded by this gene interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. Alternative splice variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
