The DDX41 Polyclonal Antibody (CAB6576) is a high-quality research tool designed for studies involving DDX41, a protein known for its role in immune responses and antiviral defense mechanisms. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the DDX41 protein, researchers can easily detect and analyze its expression levels in a variety of cell types.DDX41 is a vital component of the innate immune system, functioning as a sensor for detecting viral nucleic acids and initiating immune responses to combat infections.
Its involvement in antiviral immunity makes it a promising target for research aimed at understanding viral pathogenesis and developing novel antiviral therapies. By studying the functions of DDX41, researchers can gain insights into the mechanisms underlying viral recognition and immune activation, ultimately leading to the development of new strategies for combating viral infections and enhancing immune responses.
Product Name:
DDX41 Rabbit Polyclonal Antibody
SKU:
CAB6576
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human DDX41 (NP_057306.2).
WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:100 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Synonyms:
ABS; MPLPF; DDX41
Positive Sample:
Rat testis
Conjugate:
Unconjugated
Cellular Localization:
Nucleus.
Calculated MW:
70kDa
Observed MW:
72kDa
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a member of the DEAD box protein family and interacts with several spliceosomal proteins. In addition, the encoded protein may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response.
Purification Method:
Affinity purification
Gene ID:
51428
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat testis, using DDX41 Rabbit pAb (CAB6576) at 1:900 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
