The DDX39B Polyclonal Antibody (CAB8356) is a valuable tool for researchers studying the DDX39B protein, a member of the DEAD-box RNA helicase family involved in RNA processing and splicing. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting DDX39B in human samples, making it ideal for applications such as Western blotting.DDX39B plays a critical role in RNA metabolism, including mRNA export from the nucleus and spliceosome assembly. Dysregulation of DDX39B has been implicated in various diseases, including cancer and neurological disorders, highlighting its importance in cellular processes.
The DDX39B Polyclonal Antibody allows for accurate detection and analysis of DDX39B levels in different cell types, providing valuable insights for research in molecular biology and disease mechanisms.By utilizing the DDX39B Polyclonal Antibody, researchers can uncover the functional roles of DDX39B in RNA processing pathways and its impact on disease development. This antibody serves as a reliable tool for investigating the biological functions of DDX39B and its potential as a therapeutic target in various pathological conditions.
Product Name:
UAP56/DDX39B Rabbit Polyclonal Antibody
SKU:
CAB8356
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 319-428 of human UAP56/UAP56/DDX39B (NP_004631.1).
This gene encodes a member of the DEAD box family of RNA-dependent ATPases that mediate ATP hydrolysis during pre-mRNA splicing. The encoded protein is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. This gene belongs to a cluster of genes localized in the vicinity of the genes encoding tumor necrosis factor alpha and tumor necrosis factor beta. These genes are all within the human major histocompatibility complex class III region. Mutations in this gene may be associated with rheumatoid arthritis. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on both chromosomes 6 and 11. Read-through transcription also occurs between this gene and the upstream ATP6V1G2 (ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2) gene.
Purification Method:
Affinity purification
Gene ID:
7919
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using UAP56/DDX39B Rabbit pAb (CAB8356) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
