The DDX39A Polyclonal Antibody (CAB12558) is an essential tool for researchers studying DDX39A, a crucial protein involved in RNA processing and gene expression regulation. This antibody, developed using rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the DDX39A protein, researchers can accurately detect and analyze its presence in a variety of cell types, making it an ideal choice for studies in molecular biology and cancer research.DDX39A, also known as UAP56, plays a pivotal role in RNA metabolism by facilitating the splicing and export of mRNA molecules.
Dysregulation of DDX39A has been linked to various diseases, including cancer and neurodevelopmental disorders, highlighting its importance in cellular functions. By exploring the function of DDX39A, researchers can gain valuable insights into the mechanisms of disease and potential therapeutic targets for intervention.Overall, the DDX39A Polyclonal Antibody (CAB12558) serves as a valuable tool for researchers seeking to unravel the intricacies of RNA processing and gene expression, paving the way for advancements in the understanding and treatment of various diseases.
Product Name:
DDX39A Rabbit Polyclonal Antibody
SKU:
CAB12558
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 178-427 of human DDX39A (NP_005795.2).
This gene encodes a member of the DEAD box protein family. These proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD) and are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene is thought to play a role in the prognosis of patients with gastrointestinal stromal tumors. A pseudogene of this gene is present on chromosome 13. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
Purification Method:
Affinity purification
Gene ID:
10212
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using DDX39A antibody (CAB12558) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
