The DDX23 Polyclonal Antibody (PACO08786) is specifically designed for researchers studying DDX23, a crucial component in RNA processing and gene expression regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the DDX23 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it an essential tool for investigations in molecular biology and genetics.DDX23, a member of the DEAD-box RNA helicase family, is involved in various cellular processes, including RNA splicing, translation, and mRNA export.
Its role in regulating gene expression makes it a key player in cellular development and homeostasis. By understanding the function of DDX23, researchers can gain insights into diseases related to RNA processing dysregulation, such as cancer and neurodegenerative disorders. Investigating the mechanisms of DDX23 activity may lead to the development of novel therapies targeting these conditions.
DEAD (Asp-Glu-Ala-Asp) box polypeptide 23;DDX23;MGC8416;PRPF28;U5-100K;U5-100KD;prp28 ;
UniProt Protein Function:
DDX23: Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.Protein type: Helicase; RNA-binding; RNA processing; RNA splicing; EC 3.6.4.13; SpliceosomeChromosomal Location of Human Ortholog: 12q13.12Cellular Component: nucleoplasm; mitochondrion; snRNP U5; nucleolus; plasma membrane; nucleusMolecular Function: protein binding; ATP-dependent helicase activity; ATP binding; ATP-dependent RNA helicase activityBiological Process: nuclear mRNA splicing, via spliceosome; RNA splicing, via transesterification reactions; cis assembly of pre-catalytic spliceosome; RNA splicing; gene expression
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the U5 snRNP complex; it may facilitate conformational changes in the spliceosome during nuclear pre-mRNA splicing. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined. [provided by RefSeq, Jul 2008]
