The DDX21 Polyclonal Antibody (CAB7034) is a valuable tool for researchers studying the DDX21 protein, a key player in RNA metabolism and innate immune response pathways. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications including Western blot and immunofluorescence. By targeting the DDX21 protein, researchers can effectively detect and analyze its expression in different cell types, making it an essential tool for studies in virology, immunology, and oncology.DDX21, also known as RNA helicase, plays a crucial role in various cellular processes such as RNA splicing, translation initiation, and antiviral defense mechanisms.
Its involvement in innate immunity highlights the importance of understanding its functions in immune responses and viral replication. Research on DDX21 can provide insights into viral pathogenesis, host-virus interactions, and potential therapeutic targets for viral infections and autoimmune diseases.Overall, the DDX21 Polyclonal Antibody (CAB7034) offers researchers a reliable tool to investigate the function and regulation of the DDX21 protein in diverse biological contexts, leading to advancements in our understanding of cellular processes and disease mechanisms.
Product Name:
DDX21 Rabbit Polyclonal Antibody
SKU:
CAB7034
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 624-783 of human DDX21 (NP_004719.2).
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription.
Purification Method:
Affinity purification
Gene ID:
9188
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using DDX21 antibody (CAB7034) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 60s.
