DDX19B Antibody (PACO16166)
- SKU:
- PACO16166
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
DDX19B Antibody (PACO16166)
The DDX19B Polyclonal Antibody (PACO16166) is a valuable tool for researchers studying DDX19B, a protein involved in RNA processing and transport. This antibody, generated in rabbits, exhibits high specificity and sensitivity when detecting DDX19B in human samples, making it a reliable choice for Western blot applications. By binding to the DDX19B protein, this antibody enables accurate detection and analysis in various cell types, offering important insights for studies in molecular biology and RNA metabolism.
DDX19B is an essential factor in RNA metabolism, playing a crucial role in RNA export from the nucleus to the cytoplasm. Its involvement in these processes makes it a key target for research in gene expression regulation and RNA-related disorders. By understanding the function and regulation of DDX19B, researchers can shed light on its significance in diseases such as cancer, viral infections, and neurological disorders, paving the way for potential therapeutic interventions targeting RNA processing pathways.
| Antibody Name: | DDX19B Antibody (PACO16166) |
| Antibody SKU: | PACO16166 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Fusion protein of human DDX19B |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO16166(DDX19B Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
 | Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hela cells, 293T cells, Primary antibody: PACO16166(DDX19B Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using PACO16166(DDX19B Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which exhibits RNA-dependent ATPase and ATP-dependent RNA-unwinding activities. This protein is recruited to the cytoplasmic fibrils of the nuclear pore complex, where it participates in the export of mRNA from the nucleus. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Synonyms: | DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B |
| UniProt Protein Function: | DDX19B: ATP-dependent RNA helicase involved in mRNA export from the nucleus. Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.6.4.13; Helicase; RNA-bindingChromosomal Location of Human Ortholog: 16q22.1Cellular Component: cytoplasm; membrane; nuclear envelope; nuclear membrane; nuclear pore; nucleusMolecular Function: ATP binding; ATP-dependent RNA helicase activity; helicase activity; protein binding; RNA bindingBiological Process: mRNA export from nucleus; protein transport; RNA secondary structure unwinding |
| UniProt Protein Details: | |
| NCBI Summary: | DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which exhibits RNA-dependent ATPase and ATP-dependent RNA-unwinding activities. This protein is recruited to the cytoplasmic fibrils of the nuclear pore complex, where it participates in the export of mRNA from the nucleus. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UMR2 |
| NCBI GenInfo Identifier: | 10719979 |
| NCBI Gene ID: | 11269 |
| NCBI Accession: | Q9UMR2.1 |
| UniProt Secondary Accession: | Q9UMR2,Q6FIB7, Q6IAE0, Q96KE7, Q9H0U0, B3KNE9, B4DXS6 E7EMK4 |
| UniProt Related Accession: | Q9UMR2 |
| Molecular Weight: | 51,063 Da |
| NCBI Full Name: | ATP-dependent RNA helicase DDX19B |
| NCBI Synonym Full Names: | DEAD-box helicase 19B |
| NCBI Official Symbol: | DDX19BÂ Â |
| NCBI Official Synonym Symbols: | DBP5; RNAh; DDX19Â Â |
| NCBI Protein Information: | ATP-dependent RNA helicase DDX19B |
| UniProt Protein Name: | ATP-dependent RNA helicase DDX19B |
| UniProt Synonym Protein Names: | DEAD box RNA helicase DEAD5; DEAD box protein 19B |
| Protein Family: | ATP-dependent RNA helicase |
| UniProt Gene Name: | DDX19BÂ Â |
| UniProt Entry Name: | DD19B_HUMAN |
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