The DDX19B Polyclonal Antibody (PAC008783) is a valuable tool for researchers studying DDX19B, a protein involved in RNA processing and transport. This antibody is produced in rabbits and has been validated for use in Western blot applications, providing reliable detection and analysis of DDX19B in human samples.DDX19B is a crucial component in the RNA export pathway, playing a key role in the transportation of mRNA from the nucleus to the cytoplasm for translation. Research has shown that dysregulation of DDX19B activity can lead to disruptions in gene expression and cellular function, making it a potential target for studies in molecular biology and oncology.
By utilizing the DDX19B Polyclonal Antibody, researchers can gain valuable insights into the function and regulation of DDX19B in various cellular processes. This antibody opens up opportunities for further exploration into RNA metabolism and the development of new therapeutics targeting DDX19B-related pathways.
DEAD (Asp-Glu-Ala-As) box polypeptide 19B;DDX19B;DBP5;DDX19;RNAh ;
UniProt Protein Function:
DDX19B: ATP-dependent RNA helicase involved in mRNA export from the nucleus. Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.6.4.13; Helicase; RNA-bindingChromosomal Location of Human Ortholog: 16q22.1Cellular Component: cytoplasm; membrane; nuclear envelope; nuclear membrane; nuclear pore; nucleusMolecular Function: ATP binding; ATP-dependent RNA helicase activity; helicase activity; protein binding; RNA bindingBiological Process: mRNA export from nucleus; protein transport; RNA secondary structure unwinding
UniProt Protein Details:
NCBI Summary:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which exhibits RNA-dependent ATPase and ATP-dependent RNA-unwinding activities. This protein is recruited to the cytoplasmic fibrils of the nuclear pore complex, where it participates in the export of mRNA from the nucleus. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
