The DDX19B Polyclonal Antibody (PACO00691) is a valuable tool for researchers studying DDX19B, a protein involved in RNA processing and RNA export. Raised in rabbits, this antibody exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to DDX19B, this antibody enables precise detection and analysis of the protein in various cell types, making it an ideal choice for studies in molecular biology and RNA research.DDX19B is a critical component of the RNA export machinery, playing a crucial role in the regulation of gene expression and cellular functions.
Its importance in RNA processing makes it a key target for research in areas such as cancer biology, virology, and developmental biology. Understanding the function of DDX19B is essential for unraveling the intricate mechanisms underlying gene expression and RNA metabolism, paving the way for the development of novel therapeutic interventions targeting RNA-related diseases.
Antibody Name:
DDX19B Antibody
Antibody SKU:
PACO00691
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human, Mouse
Immunogen:
synthesized peptide derived from the N-terminal region of human DDX19B.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
DDX19B; DBP5; DDX19; TDBP; ATP-dependent RNA helicase DDX19B; DEAD box RNA helicase DEAD5; DEAD box protein 19B
UniProt Protein Function:
DDX19B: ATP-dependent RNA helicase involved in mRNA export from the nucleus. Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.6.4.13; Helicase; RNA-bindingChromosomal Location of Human Ortholog: 16q22.1Cellular Component: cytoplasm; membrane; nuclear envelope; nuclear membrane; nuclear pore; nucleusMolecular Function: ATP binding; ATP-dependent RNA helicase activity; helicase activity; protein binding; RNA bindingBiological Process: mRNA export from nucleus; protein transport; RNA secondary structure unwinding
UniProt Protein Details:
NCBI Summary:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which exhibits RNA-dependent ATPase and ATP-dependent RNA-unwinding activities. This protein is recruited to the cytoplasmic fibrils of the nuclear pore complex, where it participates in the export of mRNA from the nucleus. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
