The DDR2 Polyclonal Antibody (CAB10060) is a valuable tool for researchers studying DDR2, a cell surface receptor involved in collagen remodeling and fibrosis. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the DDR2 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it ideal for investigations in the fields of fibrosis, cancer, and tissue remodeling.DDR2, a receptor for collagen and extracellular matrix proteins, plays a crucial role in cell migration, adhesion, and proliferation.
Dysregulation of DDR2 has been implicated in various diseases, including fibrotic disorders, arthritis, and certain types of cancer. Research into the function and regulation of DDR2 is essential for identifying potential therapeutic targets and developing treatments for these conditions. By using the DDR2 Polyclonal Antibody (CAB10060), researchers can gain valuable insights into the role of DDR2 in disease pathology and explore new strategies for the management and treatment of fibrosis-related disorders.
Product Name:
DDR2 Rabbit Polyclonal Antibody
SKU:
CAB10060
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 290-400 of human DDR2 (NP_001014796.1).
Sequence:
NMFA KGVK IFKE VQCY FRSE ASEW EPNA ISFP LVLD DVNP SARF VTVP LHHR MASA IKCQ YHFA DTWM MFSE ITFQ SDAA MYNN SEAL PTSP MAPT TYDP MLKV DDSN TRI
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
97kDa
Observed MW:
110kDa
This gene encodes a member of the discoidin domain receptor subclass of the receptor tyrosine kinase (RTKs) protein family. RTKs play a key role in the communication of cells with their microenvironment. The encoded protein is a collagen-induced receptor that activates signal transduction pathways involved in cell adhesion, proliferation, and extracellular matrix remodeling. This protein is expressed in numerous cell types and may alos be involved in wound repair and regulate tumor growth and invasiveness. Mutations in this gene are the cause of short limb-hand type spondylometaepiphyseal dysplasia.
Purification Method:
Affinity purification
Gene ID:
4921
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using DDR2 antibody (CAB10060) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
