The DDR1 (MCK10) CD167a Monoclonal Antibody is a powerful tool for researchers studying the DDR1 protein, which plays a key role in cell adhesion and migration. This antibody, developed through mouse hybridoma technology, is highly specific and reliable for detecting DDR1 in various biological samples. It has been validated for use in immunofluorescence, immunoprecipitation, and flow cytometry applications.DDR1 is a receptor tyrosine kinase involved in cellular processes such as cell proliferation, differentiation, and survival.
Dysregulation of DDR1 has been implicated in various diseases, including cancer and fibrosis, making it an important target for therapeutic development. By using the DDR1 (MCK10) CD167a Monoclonal Antibody, researchers can gain valuable insights into the function and signaling pathways of DDR1, advancing our understanding of its role in health and disease.
Product Name:
DDR1/MCK10/CD167a Monoclonal Antibody
SKU:
CAB22705
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 21-416 of human DDR1/MCK10/CD167a(NP_054699.2).
Cell membrane, Secreted, Single-pass type I membrane protein.
Calculated MW:
101kDa
Observed MW:
125kDa
Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Purification Method:
Affinity purification
Gene ID:
780
Clone Number:
ARC58637
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of Mouse brain, using DDR1/MCK10/CD167a antibody (CAB22705) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
