The DDIT4L Polyclonal Antibody (PACO16165) is a valuable tool for researchers studying the DDIT4L protein, a key player in cellular stress responses and autophagy regulation. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it an ideal choice for Western blot applications. By targeting the DDIT4L protein, researchers can gain insights into its function and signaling pathways in various cell types, advancing our understanding of its role in processes such as apoptosis, metabolism, and cancer development.
DDIT4L, also known as RTP801L, is involved in cellular responses to stress conditions, such as nutrient deprivation and hypoxia. Its dysregulation has been linked to diseases like cancer, diabetes, and neurodegenerative disorders, highlighting its importance as a potential therapeutic target. By studying the function of DDIT4L, researchers can uncover new strategies for treating and preventing these conditions, ultimately improving patient outcomes and advancing the field of molecular biology.
Antibody Name:
DDIT4L Antibody (PACO16165)
Antibody SKU:
PACO16165
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Fusion protein of human DDIT4L
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO16165(DDIT4L Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16165(DDIT4L Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
Background:
REDD-2 (regulated in development and DNA damage response 2), also designated Rtp801L or DDIT4L (DNA-damage-inducible transcript 4-like), is a 193 amino acid, cytoplasmic protein belonging to the DDIT4 family and is predominantly expressed in skeletal muscle. Considered a stress-inducted protein, REDD-2 is a negative regulator of the mTOR (mammalian target of rapamycin) pathway. mTOR is a serine/threonine kinase that plays an essential role in cell growth control and is an important regulator of skeletal muscle size. Highly expressed in human atherosclerotic lesions and macrophages, REDD-2 mediates monocyte cell death through reduction of Trx (thioredoxin-1) expression. REDD2 expression in macrophages increases oxidized LDL (oxLDL)-induced cell death, suggesting that REDD2 may play a critical role in arterial pathology.
Synonyms:
DNA-damage-inducible transcript 4-like
UniProt Protein Function:
DDIT4L: Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1. Belongs to the DDIT4 family.Protein type: Unknown functionChromosomal Location of Human Ortholog: 4q24Cellular Component: cytoplasmMolecular Function: protein binding
