Anti-DDIT4L Antibody (PACO16165)

Antibody Name:	DDIT4L Antibody (PACO16165)
Antibody SKU:	PACO16165
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:	Human, Mouse, Rat
Immunogen:	Fusion protein of human DDIT4L

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO16165(DDIT4L Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
	The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16165(DDIT4L Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).

Background:

REDD-2 (regulated in development and DNA damage response 2), also designated Rtp801L or DDIT4L (DNA-damage-inducible transcript 4-like), is a 193 amino acid, cytoplasmic protein belonging to the DDIT4 family and is predominantly expressed in skeletal muscle. Considered a stress-inducted protein, REDD-2 is a negative regulator of the mTOR (mammalian target of rapamycin) pathway. mTOR is a serine/threonine kinase that plays an essential role in cell growth control and is an important regulator of skeletal muscle size. Highly expressed in human atherosclerotic lesions and macrophages, REDD-2 mediates monocyte cell death through reduction of Trx (thioredoxin-1) expression. REDD2 expression in macrophages increases oxidized LDL (oxLDL)-induced cell death, suggesting that REDD2 may play a critical role in arterial pathology.

Synonyms:

DNA-damage-inducible transcript 4-like

UniProt Protein Function:	DDIT4L: Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1. Belongs to the DDIT4 family.Protein type: Unknown functionChromosomal Location of Human Ortholog: 4q24Cellular Component: cytoplasmMolecular Function: protein binding
UniProt Protein Details:
NCBI Summary:
UniProt Code:	Q96D03
NCBI GenInfo Identifier:	74731396
NCBI Gene ID:	115265
NCBI Accession:	Q96D03.1
UniProt Secondary Accession:	Q96D03,B2R7C3
UniProt Related Accession:	Q96D03
Molecular Weight:	21,740 Da
NCBI Full Name:	DNA damage-inducible transcript 4-like protein
NCBI Synonym Full Names:	DNA damage inducible transcript 4 like
NCBI Official Symbol:	DDIT4L
NCBI Official Synonym Symbols:	REDD2; Rtp801L
NCBI Protein Information:	DNA damage-inducible transcript 4-like protein
UniProt Protein Name:	DNA damage-inducible transcript 4-like protein
UniProt Synonym Protein Names:	HIF-1 responsive protein RTP801-like; Protein regulated in development and DNA damage response 2; REDD-2
Protein Family:	DNA damage-inducible transcript 4-like protein
UniProt Gene Name:	DDIT4L
UniProt Entry Name:	DDT4L_HUMAN

Antibodies

DDIT4L Antibody (PACO08779)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)