The DDIT4L Polyclonal Antibody (PACO16164) is a valuable tool for researchers studying DDIT4L, a protein involved in cellular stress response and metabolism regulation. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the DDIT4L protein, the antibody enables the detection and analysis of DDIT4L in a variety of cell types, making it ideal for studies in cell biology and metabolism research.
DDIT4L, also known as REDD2, plays a crucial role in the regulation of cell growth and survival in response to changes in nutrient availability and stress conditions. Its involvement in metabolic pathways and stress response mechanisms makes it a promising target for research into diseases such as cancer and metabolic disorders. By elucidating the function of DDIT4L, researchers can uncover potential therapeutic strategies for addressing these conditions and improving patient outcomes.
Antibody Name:
DDIT4L Antibody (PACO16164)
Antibody SKU:
PACO16164
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Fusion protein of human DDIT4L
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO16164(DDIT4L Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
Background:
REDD-2 (regulated in development and DNA damage response 2), also designated Rtp801L or DDIT4L (DNA-damage-inducible transcript 4-like), is a 193 amino acid, cytoplasmic protein belonging to the DDIT4 family and is predominantly expressed in skeletal muscle. Considered a stress-inducted protein, REDD-2 is a negative regulator of the mTOR (mammalian target of rapamycin) pathway. mTOR is a serine/threonine kinase that plays an essential role in cell growth control and is an important regulator of skeletal muscle size. Highly expressed in human atherosclerotic lesions and macrophages, REDD-2 mediates monocyte cell death through reduction of Trx (thioredoxin-1) expression. REDD2 expression in macrophages increases oxidized LDL (oxLDL)-induced cell death, suggesting that REDD2 may play a critical role in arterial pathology.
Synonyms:
DNA-damage-inducible transcript 4-like
UniProt Protein Function:
DDIT4L: Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1. Belongs to the DDIT4 family.Protein type: Unknown functionChromosomal Location of Human Ortholog: 4q24Cellular Component: cytoplasmMolecular Function: protein binding
