The DDB2 Rabbit Monoclonal Antibody is a valuable tool for researchers studying DNA damage-binding protein 2 (DDB2), a key player in the DNA damage response pathway. This antibody, produced in rabbits, is highly specific and sensitive for detecting DDB2 protein in human samples, making it ideal for use in Western blot assays.DDB2 is essential for the recognition and repair of DNA damage caused by various sources, including UV radiation and chemical agents. Dysregulation of DDB2 has been linked to genomic instability and increased cancer risk, making it a promising target for cancer research and drug development.
By using the DDB2 Rabbit Monoclonal Antibody, researchers can investigate the role of DDB2 in DNA repair processes and its implications for cancer therapy.Overall, the DDB2 Rabbit Monoclonal Antibody is a reliable tool for studying the functions of DDB2 in DNA damage repair pathways, offering insights into potential therapeutic strategies for cancer and other diseases associated with genomic instability.
Product Name:
DDB2 Rabbit Monoclonal Antibody
SKU:
CAB11615
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 220-427 of human DDB2 (Q92466).
This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
1643
Clone Number:
ARC0644
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using DDB2 Rabbit mAb (CAB11615) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
