DDB2 Rabbit Monoclonal Antibody (CAB11615)
- SKU:
- CAB11615
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | DDB2 Rabbit Monoclonal Antibody |
SKU: | CAB11615 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 220-427 of human DDB2 (Q92466). |
Sequence: | DNVG NVIL LNMD GKEL WNLR MHKK KVTH VALN PCCD WFLA TASV DQTV KIWD LRQV RGKA SFLY SLPH RHPV NAAC FSPD GARL LTTD QKSE IRVY SASQ WDCP LGLI PHPH RHFQ HLTP IKAA WHPR YNLI VVGR YPDP NFKS CTPY ELRT IDVF DGNS GKMM CQLY DPES SGIS SLNE FNPM GDTL ASAM GYHI LIWS QEEA RTRK |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | XPE; DDBB; UV-DDB2; DDB2 |
Positive Sample: | HeLa,U-87MG,Mouse lung |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 48kDa |
Observed MW: | 48kDa |
This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 1643 |
Clone Number: | ARC0644 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |