DDB2 Polyclonal Antibody (CAB21374)
- SKU:
- CAB21374
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- IF
Frequently bought together:
Description
Product Name: | DDB2 Polyclonal Antibody |
SKU: | CAB21374 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-315 of human DDB2 (NP_000098.1). |
Sequence: | MAPK KRPE TQKT SEIV LRPR NKRS RSPL ELEP EAKK LCAK GSGP SRRC DSDC LWVG LAGP QILP PCRS IVRT LHQH KLGR ASWP SVQQ GLQQ SFLH TLDS YRIL QKAA PFDR RATS LAWH PTHP STVA VGSK GGDI MLWN FGIK DKPT FIKG IGAG GSIT GLKF NPLN TNQF YASS MEGT TRLQ DFKG NILR VFAS SDTI NIWF CSLD VSAS SRMV VTGD NVGN VILL NMDG KELW NLRM HKKK VTHV ALNP CCDW FLAT ASVD QTVK IWDL RQVR GKAS FLYS LPHR HPVN AACF SPDG ARLL TTDQ KSEI RVY |
Tested Applications: | IF/ICC ELISA |
Recommended Dilution: | IF/ICC,1:50 - 1:200 |
Synonyms: | XPE; DDBB; UV-DDB2; DDB2 |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 48kDa |
Observed MW: | Refer to figures |
This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 1643 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |