The DDB2 Polyclonal Antibody is a valuable tool for researchers studying DNA damage-binding protein 2 (DDB2), which plays a key role in DNA repair processes. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for use in Western blot applications.DDB2 is essential for recognizing UV-induced DNA damage and initiating nucleotide excision repair, making it a crucial component in maintaining genomic stability and preventing mutations that can lead to cancer development. By targeting DDB2 with this polyclonal antibody, researchers can accurately detect and quantify the protein in various cell types, allowing for detailed analysis of DNA repair mechanisms.
Furthermore, the ability to study DDB2 expression and localization in cells offers insights into how this protein functions in response to different types of DNA damage, providing valuable information for cancer research and understanding the molecular mechanisms underlying DNA repair pathways. The DDB2 Polyclonal Antibody is a reliable tool for advancing research in the fields of genomics, oncology, and molecular biology.
Product Name:
DDB2 Polyclonal Antibody
SKU:
CAB21374
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-315 of human DDB2 (NP_000098.1).
This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
1643
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunofluorescence analysis of MCF-7 cells using DDB2 antibody (CAB21374). Blue: DAPI for nuclear staining.
