The DDB1 Rabbit Monoclonal Antibody (CAB5022) is a cutting-edge tool for researchers studying DDB1, a key protein involved in various cellular processes. This highly specific antibody, developed using innovative rabbit monoclonal technology, is ideal for detecting and analyzing DDB1 in human samples. Validated for use in Western blot applications, this antibody binds specifically to DDB1, allowing for accurate and reliable results in a variety of cell types.DDB1, also known as DNA damage-binding protein 1, plays a crucial role in DNA repair and cell cycle regulation. Dysregulation of DDB1 has been implicated in cancer development and progression, making it a promising target for cancer research.
By utilizing this antibody, researchers can gain valuable insights into the role of DDB1 in cancer biology and potentially uncover new therapeutic strategies for treating this devastating disease.Overall, the DDB1 Rabbit Monoclonal Antibody (CAB5022) is a powerful tool for investigating the function of DDB1 in cellular processes, particularly in the context of cancer research. Its high reactivity and specificity make it a valuable asset for scientists seeking to deepen their understanding of DDB1 and its implications in disease pathology.
Product Name:
DDB1 Rabbit Monoclonal Antibody
SKU:
CAB5022
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1041-1140 of human DDB1 (NP_001914.3).
The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins.
Purification Method:
Affinity purification
Gene ID:
1642
Clone Number:
ARC1278
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using DDB1 Rabbit mAb (CAB5022) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
