DDB1 Rabbit Polyclonal Antibody (CAB2896)
- SKU:
- CAB2896
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | DDB1 Rabbit Polyclonal Antibody |
SKU: | CAB2896 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 741-1140 of human DDB1 (NP_001914.3). |
Sequence: | EVQD TSGG TTAL RPSA STQA LSSS VSSS KLFS SSTA PHET SFGE EVEV HNLL IIDQ HTFE VLHA HQFL QNEY ALSL VSCK LGKD PNTY FIVG TAMV YPEE AEPK QGRI VVFQ YSDG KLQT VAEK EVKG AVYS MVEF NGKL LASI NSTV RLYE WTTE KELR TECN HYNN IMAL YLKT KGDF ILVG DLMR SVLL LAYK PMEG NFEE IARD FNPN WMSA VEIL DDDN FLGA ENAF NLFV CQKD SAAT TDEE RQHL QEVG LFHL GEFV NVFC HGSL VMQN LGET STPT QGSV LFGT VNGM IGLV TSLS ESWY NLLL DMQN RLNK VIKS VGKI EHSF WRSF HTER KTEP ATGF IDGD LIES FLDI SRPK MQEV VANL QYDD GSGM KREA TADD LIKV VEEL TRIH |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:100 IF/ICC,1:50 - 1:100 |
Synonyms: | XPE; DDBA; XAP1; XPCE; XPE-BF; UV-DDB1; WHIKERS; DDB1 |
Positive Sample: | BT-474,SW620,293T,Mouse eye,Mouse testis,Mouse breast |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 127kDa |
Observed MW: | 127kDa |
The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins.
Purification Method: | Affinity purification |
Gene ID: | 1642 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |