The DDAH2 Polyclonal Antibody (CAB6457) is a valuable tool for researchers studying DDAH2, an enzyme involved in the regulation of nitric oxide production and cardiovascular function. This antibody, produced in rabbits, exhibits high specificity and sensitivity for human samples, making it an ideal choice for Western blot applications. By targeting the DDAH2 protein, this antibody enables precise detection and analysis in a variety of cell types, facilitating research in cardiovascular disease, hypertension, and other conditions related to nitric oxide dysregulation.
DDAH2, also known as dimethylarginine dimethylaminohydrolase 2, plays a crucial role in modulating nitric oxide levels by metabolizing endogenous inhibitors of nitric oxide synthase. Dysregulation of DDAH2 activity has been implicated in various cardiovascular disorders, making it a promising target for therapeutic intervention. By studying the function of DDAH2, researchers can gain valuable insights into the mechanisms underlying cardiovascular pathology and potentially identify novel treatment strategies.
Product Name:
DDAH2 Rabbit Polyclonal Antibody
SKU:
CAB6457
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Not found
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-285 of human DDAH2 (NP_039268.1).
This gene encodes a dimethylarginine dimethylaminohydrolase. The encoded enzyme functions in nitric oxide generation by regulating the cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity. The protein may be localized to the mitochondria. Alternative splicing resulting in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
23564
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using DDAH2 antibody (CAB6457) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
