The DDA1 Polyclonal Antibody (PAC051082) is a valuable tool for researchers studying DDA1, a protein involved in the regulation of protein degradation and cell proliferation. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for use in Western blot applications. By targeting the DDA1 protein, this antibody facilitates the detection and analysis of DDA1 in various cell types, making it well-suited for research in cell biology and cancer studies.
DDA1, also known as DDA1-like protein, plays a crucial role in the ubiquitin-proteasome pathway, which is essential for maintaining protein homeostasis within cells. Dysregulation of this pathway has been implicated in various diseases, including cancer and neurodegenerative disorders. By investigating the function of DDA1, researchers can gain insights into the molecular mechanisms underlying these pathologies and potentially identify new therapeutic targets for intervention.
Western Blot. Positive WB detected in: Rat liver tissue, Mouse liver tissue. All lanes: DDA1 antibody at 2.8µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 12 kDa. Observed band size: 12 kDa..
Immunofluorescent analysis of PC-3 cells using PACO51082 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO51082 at dilution of 1:100.
Background:
May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of the DDD-E2 complexes which may provide a platform for interaction with CUL4A and WD repeat proteins.
Synonyms:
DET1- and DDB1-associated protein 1 (Placenta cross-immune reaction antigen 1) (PCIA-1), DDA1, C19orf58 PCIA1
UniProt Protein Function:
DDA1: May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of the DDD- E2 complexes which may provide a platform for interaction with CUL4A and WD repeat proteins. Belongs to the DDA1 family.Protein type: Ubiquitin conjugating system; AutophagyChromosomal Location of Human Ortholog: 19p13.11Molecular Function: protein binding
