The DCX Rabbit Monoclonal Antibody (CAB19042) is a powerful tool for researchers studying the role of Doublecortin (DCX) in neurogenesis and neuronal migration. This antibody, raised in rabbits, exhibits high specificity and sensitivity for detecting DCX protein in various experimental settings, including immunofluorescence and immunohistochemistry. DCX is a microtubule-associated protein essential for proper brain development, particularly in the migration of neurons during neurogenesis. Dysregulation of DCX expression has been implicated in neurodevelopmental disorders such as lissencephaly and epilepsy.
By targeting DCX with this monoclonal antibody, researchers can gain insights into the mechanisms underlying these conditions and potentially identify novel therapeutic targets.With its superior performance in detecting DCX protein levels, the DCX Rabbit Monoclonal Antibody (CAB19042) is an indispensable tool for investigating neurodevelopmental processes and exploring potential interventions for neurological disorders. Trust in this antibody for reliable and reproducible results in your research endeavors related to DCX and brain development.
Product Name:
DCX Rabbit Monoclonal Antibody
SKU:
CAB19042
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Doublecortin (O43602).
This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, cognitive disability, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
1641
Clone Number:
ARC0380
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Doublecortin antibody (CAB19042) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
