DCX Rabbit Monoclonal Antibody (CAB19042)
- SKU:
- CAB19042
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Developmental Biology
Description
Product Name: | DCX Rabbit Monoclonal Antibody |
SKU: | CAB19042 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Doublecortin (O43602). |
Sequence: | MELD FGHF DERD KTSR NMRG SRMN GLPS PTHS AHCS FYRT RTLQ ALSN EKKA KKVR FYRN GDRY FKGI VYAV SSDR FRSF DALL ADLT RSLS DNIN LPQG |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | DC; DBCN; LISX; SCLH; XLIS; Doublecortin |
Positive Sample: | C6,Mouse brain,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cell projection, Cytoplasm. |
Calculated MW: | 41kDa |
Observed MW: | 45kDa |
This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, cognitive disability, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 1641 |
Clone Number: | ARC0380 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |