The DCX Polyclonal Antibody (CAB1134) is a powerful tool for researchers studying the DCX protein, which is important for neuronal migration and development in the brain. This antibody, produced in rabbits, shows strong reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the DCX protein, this antibody allows for accurate detection and analysis in various cell types, making it ideal for studies in neuroscience and neurodevelopmental disorders.DCX, also known as doublecortin, is crucial for proper neuronal migration and organization in the developing brain. Mutations in the DCX gene have been linked to disorders like lissencephaly and subcortical band heterotopia, highlighting its importance in brain development.
Research on the function of DCX is essential for understanding neurodevelopmental processes and may provide insights into potential treatments for neurological disorders.By using the DCX Polyclonal Antibody (CAB1134), researchers can uncover valuable information about the role of DCX in brain development and function, ultimately contributing to advancements in the field of neuroscience and potentially leading to the development of novel therapies for neurodevelopmental disorders.
Product Name:
DCX Rabbit Polyclonal Antibody
SKU:
CAB1134
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 265-365 of human Doublecortin (NP_835365.1).
This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, cognitive disability, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
1641
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using Doublecortin Rabbit pAb (CAB1134) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
