The DCUN1D2 Polyclonal Antibody (PAC036974) is a valuable tool for researchers studying DCUN1D2, a protein involved in the regulation of neddylation, a post-translational modification process crucial for cell cycle regulation and protein stability. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it an ideal choice for Western blot experiments. By targeting the DCUN1D2 protein, this antibody facilitates the visualization and analysis of neddylation processes in various cell types, offering insights into its role in cancer development and progression.
DCUN1D2, also known as Renal Carcinoma Antigen NY-REN-43, is a key player in the neddylation pathway, which regulates the activity of various proteins involved in cell proliferation, survival, and differentiation. Dysregulation of neddylation has been implicated in the pathogenesis of multiple human cancers, making DCUN1D2 an attractive target for anticancer drug development. Research into the functions of DCUN1D2 is crucial for uncovering new therapeutic strategies that target neddylation in cancer treatment and precision medicine approaches.
Antibody Name:
DCUN1D2 Antibody (PACO36974)
Antibody SKU:
PACO36974
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Human
Immunogen:
Recombinant Human DCN1-like protein 2 protein (1-259AA)
Potently stimulates the neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes from the NEDD8-conjugating E2 enzyme UBC12. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.
Synonyms:
DCN1-like protein 2 (DCUN1 domain-containing protein 2) (Defective in cullin neddylation protein 1-like protein 2), DCUN1D2, C13orf17 DCUN1L2
UniProt Protein Function:
DCUN1D2: May contribute to neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 13q34
