Anti-DCTN4 Antibody (PACO16156)

Antibody Name:	DCTN4 Antibody (PACO16156)
Antibody SKU:	PACO16156
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:2000-1:10000, IHC:1:100-1:300
Species Reactivity:	Human, Mouse, Rat
Immunogen:	Fusion protein of human DCTN4

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO16156(DCTN4 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
	The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO16156(DCTN4 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).

Background:

Dynactin is a multisubunit complex and a required cofactor for most, or all, of the cellular processes powered by the microtubule-based motor cytoplasmic dynein . Dynactin contains a short actin-related protein 1 (Arp1) filament with capZ at the barbed end and p62 at the pointed end . The p62 subunit is an integral component of 20 S dynactin with a highly conserved cysteine-rich motif that interacts directly with Arp1. Dynactin p62 has a punctate cytoplasmic distribution as well as centrosomal distribution typical of dynactin . In addition, Dynactin p62 is distributed in the nucleus at very high expression levels . Due to the structural composition of dynactin, the p62 subunit is implicated in Arp1 pointed-end binding and in linking dynein and dynactin to the cortical cytoskeleton.

Synonyms:

dynactin 4 (p62)

UniProt Protein Function:	dynactin 4: Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton. Belongs to the dynactin subunit 4 family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Motility/polarity/chemotaxis; Motor; Microtubule-bindingChromosomal Location of Human Ortholog: 5q33.1Cellular Component: centrosome; cytoplasm; cytoplasmic dynein complex; cytosol; dynactin complex; nucleusMolecular Function: protein binding; protein N-terminus bindingBiological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; ER to Golgi vesicle-mediated transport; nuclear migration
UniProt Protein Details:
NCBI Summary:
UniProt Code:	Q9UJW0
NCBI GenInfo Identifier:	62900106
NCBI Gene ID:	51164
NCBI Accession:	Q9UJW0.1
UniProt Secondary Accession:	Q9UJW0,Q8TAN8, B3KWW0, D3DQH0, E5RGT5
UniProt Related Accession:	Q9UJW0
Molecular Weight:	53,152 Da
NCBI Full Name:	Dynactin subunit 4
NCBI Synonym Full Names:	dynactin subunit 4
NCBI Official Symbol:	DCTN4
NCBI Official Synonym Symbols:	P62; DYN4
NCBI Protein Information:	dynactin subunit 4
UniProt Protein Name:	Dynactin subunit 4
UniProt Synonym Protein Names:	Dynactin subunit p62
Protein Family:	Dynactin
UniProt Gene Name:	DCTN4
UniProt Entry Name:	DCTN4_HUMAN

Antibodies

DCTN4 Antibody (PACO08765)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)