The DCTN2 Polyclonal Antibody (CAB14841) is a valuable tool for researchers studying the DCTN2 protein, a key component of the dynactin complex involved in intracellular transport. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the DCTN2 protein, this antibody allows for accurate detection and analysis in various cell types, making it an essential component of studies in cell biology and molecular biology.DCTN2 plays a crucial role in the regulation of intracellular traffic and organelle positioning, making it a target of interest for researchers studying cellular dynamics and disease mechanisms.
Understanding the function of DCTN2 can provide insights into processes such as vesicle trafficking and organelle movement, with implications for various cellular processes and diseases. The DCTN2 Polyclonal Antibody is a valuable tool for investigating the role of DCTN2 in cellular function and disease pathology.
Product Name:
DCTN2 Rabbit Polyclonal Antibody
SKU:
CAB14841
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 280-401 of human DCTN2 (NP_006391.1).
This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
10540
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using DCTN2 Rabbit pAb (CAB14841) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
