DCTN1 Rabbit Polyclonal Antibody (CAB1783)
- SKU:
- CAB1783
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Description
Product Name: | DCTN1 Rabbit Polyclonal Antibody |
SKU: | CAB1783 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 945-1139 of human DCTN1 (NP_001128513.1). |
Sequence: | PGLV KDSP LLLQ QISA MRLH ISQL QHEN SILK GAQM KASL ASLP PLHV AKLS HEGP GSEL PAGA LYRK TSQL LETL NQLS THTH VVDI TRTS PAAK SPSA QLME QVAQ LKSL SDTV EKLK DEVL KETV SQRP GATV PTDF ATFP SSAF LRAK EEQQ DDTV YMGK VTFS CAAG FGQR HRLV LTQE QLHQ LHSR LIS |
Tested Applications: | WB IP ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | P135; DP-150; DAP-150; DCTN1 |
Positive Sample: | U-251MG,HeLa,HepG2,22RV1,Jurkat,Mouse testis,Rat testis |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, cytoskeleton. |
Calculated MW: | 142kDa |
Observed MW: | 150kDa |
This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA).
Purification Method: | Affinity purification |
Gene ID: | 1639 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |