The DCLRE1C Polyclonal Antibody (CAB5615) is a valuable tool for researchers studying DCLRE1C, a key protein involved in DNA repair mechanisms. This rabbit polyclonal antibody is highly specific to human samples and has been validated for use in Western blot applications. By binding to the DCLRE1C protein, this antibody allows for precise detection and analysis in various cell types, making it ideal for research in genomics, oncology, and genetic diseases.DCLRE1C, also known as ARTEMIS, is essential for repairing DNA double-strand breaks and maintaining genomic stability.
Mutations in the DCLRE1C gene have been linked to immunodeficiency disorders and predisposition to cancer. Understanding the role of DCLRE1C in DNA repair pathways is crucial for developing targeted therapies and improving treatment strategies for patients with genetic disorders and cancer. The DCLRE1C Polyclonal Antibody provides researchers with a reliable tool to investigate the function and regulation of this important protein in various biological contexts.
Product Name:
DCLRE1C Polyclonal Antibody
SKU:
CAB5615
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human DCLRE1C (NP_001029027.1).
This gene encodes a nuclear protein that is involved in V(D)J recombination and DNA repair. The encoded protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins. The protein also functions in the regulation of the cell cycle in response to DNA damage. Mutations in this gene can cause Athabascan-type severe combined immunodeficiency (SCIDA) and Omenn syndrome. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
64421
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of Mouse thymus, using DCLRE1C Rabbit pAb (CAB5615) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
