The DCK Polyclonal Antibody (CAB1794) is a powerful tool for researchers studying deoxycytidine kinase (DCK), an enzyme involved in the activation of nucleoside analog drugs commonly used in cancer treatment. This antibody, raised in rabbits, is highly specific to human DCK and has been validated for use in various applications, including Western blotting.DCK is a key player in the metabolism of nucleoside analogs like cytarabine and gemcitabine, which are used in the treatment of various cancers. By targeting DCK, researchers can better understand the mechanisms of action of these drugs and potentially improve their efficacy.
Whether studying drug resistance mechanisms, optimizing treatment strategies, or investigating new drug candidates, the DCK Polyclonal Antibody is an essential tool for researchers in the fields of oncology and pharmacology. Its high reactivity and specificity make it an ideal choice for studies aiming to unravel the complexities of nucleoside analog metabolism and drug response.
Product Name:
DCK Rabbit Polyclonal Antibody
SKU:
CAB1794
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human DCK (NP_000779.1).
Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity.
Purification Method:
Affinity purification
Gene ID:
1633
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using DCK Rabbit pAb (CAB1794) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
