DCBLD2 Antibody (PACO16145)
- SKU:
- PACO16145
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
DCBLD2 Antibody (PACO16145)
The DCBLD2 Polyclonal Antibody (PAC016145) is the ideal tool for researchers studying DCBLD2, a cell surface protein involved in various cellular processes, including angiogenesis and cancer progression. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the DCBLD2 protein, this antibody facilitates the detection and analysis of DCBLD2 in different cell types, making it a valuable asset for studies in cancer biology and vascular development.
DCBLD2, also known as ESDN, has been implicated in promoting tumor growth and metastasis in several types of cancer. Its role in angiogenesis and cell migration suggests its potential as a therapeutic target for cancer treatment. By understanding the function of DCBLD2, researchers may uncover new insights into tumor progression and identify novel strategies for inhibiting cancer spread. The DCBLD2 Polyclonal Antibody is a valuable tool for unraveling the biological mechanisms underlying DCBLD2-mediated processes and advancing cancer research.
| Antibody Name: | DCBLD2 Antibody (PACO16145) |
| Antibody SKU: | PACO16145 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:100-1:300 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Fusion protein of human DCBLD2 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO16145(DCBLD2 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO16145(DCBLD2 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | CLCP1 (CUB, LCCL and coagulation factor V/VIII-homology domains protein 1), also known as DCBLD2 (discoidin, CUB and LCCL domain containing 2) or ESDN, is a 775 amino acid, single-pass type I membrane protein that contains one CUB domain, one LCCL domain and one F5/8 type C domain. Expressed at high levels in heart, testis and skeletal muscle, CLCP1 is thought to regulate vascular smooth muscle cell (VSMC) proliferation and remodeling and may be involved in the transformation and metastasis of various cancers, such as metastatic lung cancer and gastric carcinoma. |
| Synonyms: | discoidin, CUB and LCCL domain containing 2 |
| UniProt Protein Function: | DCBLD2: a type-I transmembrane protein. May be involved in vascular remodeling and influence vascular smooth muscle cell proliferation. Contains a CUB domain and a coagulation factor V/VIII homology domain, similar to the structure of the neuropilins. Plays a role in cell motility. SEMA4B appears to be one of its ligands. Strongly expressed in nerve bundles. Highly expressed in testis, heart, skeletal muscle and also in cultured vascular smooth muscle cells. Increased in lung cancers during the process of tumor progression. A target of EGF signaling in the A431 cervical cancer cell-line. Two isoforms of the human protein are produced by alternative splicing.Protein type: Cell adhesion; Membrane protein, integralChromosomal Location of Human Ortholog: 3q12.1|3Cellular Component: cell surface; integral to plasma membraneMolecular Function: protein bindingBiological Process: negative regulation of cell growth; wound healing |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q96PD2 |
| NCBI GenInfo Identifier: | 57013820 |
| NCBI Gene ID: | 131566 |
| NCBI Accession: | Q96PD2.1 |
| UniProt Secondary Accession: | Q96PD2,Q8N6M4, Q8TDX2, B7WNL1, D3DN41 |
| UniProt Related Accession: | Q96PD2 |
| Molecular Weight: | 86,657 Da |
| NCBI Full Name: | Discoidin, CUB and LCCL domain-containing protein 2 |
| NCBI Synonym Full Names: | discoidin, CUB and LCCL domain containing 2 |
| NCBI Official Symbol: | DCBLD2Â Â |
| NCBI Official Synonym Symbols: | ESDN; CLCP1Â Â |
| NCBI Protein Information: | discoidin, CUB and LCCL domain-containing protein 2 |
| UniProt Protein Name: | Discoidin, CUB and LCCL domain-containing protein 2 |
| UniProt Synonym Protein Names: | CUB, LCCL and coagulation factor V/VIII-homology domains protein 1; Endothelial and smooth muscle cell-derived neuropilin-like protein |
| Protein Family: | Discoidin, CUB and LCCL domain-containing protein |
| UniProt Gene Name: | DCBLD2Â Â |
| UniProt Entry Name: | DCBD2_HUMAN |
| Antibodies |
| DCBLD2 Antibody (PACO08755) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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