The DCAMKL1 Rabbit Monoclonal Antibody (CAB4372) is a high-quality antibody designed for research involving DCAMKL1, a protein associated with cell proliferation and differentiation in various tissues, including the gastrointestinal tract and nervous system. This antibody, produced in rabbits, is highly specific and sensitive for detecting DCAMKL1 in human samples, making it a valuable tool for studies in cancer biology, developmental biology, and neuroscience.DCAMKL1, also known as Doublecortin and CaM kinase-like 1, is involved in various cellular processes, such as cell cycle regulation, neuronal migration, and stem cell differentiation.
Dysregulation of DCAMKL1 has been linked to tumorigenesis and neurological disorders, highlighting its importance as a potential therapeutic target. By using the CAB4372 antibody, researchers can investigate the expression and function of DCAMKL1 in different cell types and tissues, leading to a better understanding of its role in health and disease.
Product Name:
DCAMKL1/DCLK1 Rabbit Monoclonal Antibody
SKU:
CAB4372
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 600-700 of human DCAMKL1/DCLK1 (O15075).
This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.
Purification Method:
Affinity purification
Gene ID:
9201
Clone Number:
ARC0984
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using DCAMKL1/DCLK1 Rabbit mAb (CAB4372) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
