The DCAF8 Polyclonal Antibody (PAC046602) is a valuable tool for researchers studying DCAF8, a protein involved in the regulation of protein degradation and cell cycle progression. This antibody, produced in rabbits, has been validated for use in Western blot applications and is highly reactive with human samples.DCAF8 is a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex, playing a key role in the targeted degradation of specific proteins. Its involvement in cell cycle regulation and protein turnover makes it a crucial player in various cellular processes.
This antibody specifically binds to DCAF8, allowing for the detection and analysis of this protein in different cell types.Research into DCAF8 is important for understanding its function in cell cycle control, DNA repair, and tumorigenesis. The DCAF8 Polyclonal Antibody provides a reliable tool for investigating the role of DCAF8 in these processes, making it suitable for studies in molecular biology, cancer research, and drug development.
Western Blot. Positive WB detected in: Mouse heart tissue, Mouse lung tissue. All lanes: DCAF8 antibody at 3.5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 67, 31 kDa. Observed band size: 67 kDa..
Immunohistochemistry of paraffin-embedded human endometrial cancer using PACO46602 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human prostate cancer using PACO46602 at dilution of 1:100.
Background:
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
Synonyms:
DDB1- and CUL4-associated factor 8 (WD repeat-containing protein 42A), DCAF8, H326 WDR42A
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
This gene encodes a WD repeat-containing protein that interacts with the Cul4-Ddb1 E3 ligase macromolecular complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2009]
