The DCAF11 Polyclonal Antibody (CAB15519) is a valuable tool for researchers studying DCAF11, a protein that plays a key role in protein degradation and cell cycle regulation. This antibody, produced in rabbits, is highly specific to human samples and is validated for use in Western blot applications. By targeting the DCAF11 protein, this antibody allows for the detection and analysis of DCAF11 levels in various cell types, making it an excellent choice for studies in cell biology and cancer research.DCAF11 is a substrate recognition component of the E3 ubiquitin ligase complex, which plays a crucial role in maintaining cellular homeostasis by targeting specific proteins for degradation.
Understanding the function of DCAF11 is essential for unraveling the mechanisms underlying protein turnover and its implications in disease states such as cancer. This antibody provides researchers with a reliable tool to investigate the role of DCAF11 in cellular processes and potential therapeutic interventions targeting protein degradation pathways.
Product Name:
DCAF11 Rabbit Polyclonal Antibody
SKU:
CAB15519
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-170 of human DCAF11 (NP_079506.3).
This gene encodes a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. Multiple alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
80344
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of Mouse liver, using DCAF11 antibody (CAB15519) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 20s.
