The DBR1 Antibody (PAC047226) is a polyclonal antibody designed for research involving DBR1, an enzyme that plays a role in RNA metabolism. This antibody is raised in rabbits and is highly reactive with samples from various species, making it suitable for a wide range of research applications. Validated for use in Western blot and immunohistochemistry, the DBR1 Antibody specifically binds to the DBR1 protein, enabling accurate detection and analysis in different cell types.DBR1 is known for its involvement in RNA splicing and is essential for maintaining RNA stability and integrity. Dysregulation of DBR1 has been linked to various diseases, including neurological disorders and cancer.
Understanding the function and regulation of DBR1 is important for unraveling its role in disease progression and developing potential therapeutic interventions targeting this enzyme.Whether studying RNA metabolism, gene expression, or disease pathways, the DBR1 Antibody is a valuable tool for researchers in molecular biology, genetics, and biochemistry. Its high specificity and sensitivity make it a reliable reagent for investigating the functions of DBR1 and its implications in health and disease.
Antibody Name:
DBR1 Antibody (PACO47226)
Antibody SKU:
PACO47226
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Lariat debranching enzyme protein (1-220AA)
Immunohistochemistry of paraffin-embedded human thyroid tissue using PACO47226 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human gastric cancer using PACO47226 at dilution of 1:100.
Background:
Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover. It may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis.
Synonyms:
Lariat debranching enzyme (EC 3.1), DBR1
UniProt Protein Function:
DBR1: Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover. It may also participate in retrovirus replication via a RNA lariat intermediate in cDNA synthesis. Belongs to the lariat debranching enzyme family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Hydrolase; EC 3.1.-.-; RNA processing; RNA splicingChromosomal Location of Human Ortholog: 3q22.3Cellular Component: nucleusMolecular Function: RNA lariat debranching enzyme activityBiological Process: nuclear mRNA splicing, via spliceosome; RNA splicing, via transesterification reactions
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is an RNA lariat debranching enzyme that hydrolyzes 2'-5' prime branched phosphodiester bonds. The encoded protein specifically targets the bonds at the branch point of excised lariat intron RNA, converting them to linear molecules that are then degraded. This protein may also be involved in retroviral replication. [provided by RefSeq, Nov 2011]
