The DBR1 Polyclonal Antibody (PACO08753) is a valuable tool for researchers studying DBR1, a key enzyme involved in RNA metabolism and RNA degradation pathways. This antibody, produced in rabbits, exhibits high specificity and sensitivity in detecting DBR1 protein in human samples, making it ideal for Western blot applications. By targeting the DBR1 protein, researchers can explore its function in various cellular processes, providing insights into RNA regulation and potential implications in diseases such as cancer and neurodegenerative disorders.
DBR1, also known as RNA lariat debranching enzyme, plays a critical role in RNA splicing and turnover, making it a crucial player in maintaining cellular homeostasis. Dysregulation of DBR1 activity has been implicated in various diseases, highlighting the importance of studying its function and potential therapeutic interventions. By using the DBR1 Polyclonal Antibody, researchers can unravel the mechanisms underlying RNA metabolism and potentially identify novel targets for drug development in the future.
DBR1: Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover. It may also participate in retrovirus replication via a RNA lariat intermediate in cDNA synthesis. Belongs to the lariat debranching enzyme family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Hydrolase; EC 3.1.-.-; RNA processing; RNA splicingChromosomal Location of Human Ortholog: 3q22.3Cellular Component: nucleusMolecular Function: RNA lariat debranching enzyme activityBiological Process: nuclear mRNA splicing, via spliceosome; RNA splicing, via transesterification reactions
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is an RNA lariat debranching enzyme that hydrolyzes 2'-5' prime branched phosphodiester bonds. The encoded protein specifically targets the bonds at the branch point of excised lariat intron RNA, converting them to linear molecules that are then degraded. This protein may also be involved in retroviral replication. [provided by RefSeq, Nov 2011]
