The DBH Polyclonal Antibody (CAB2711) is a valuable tool for research involving dopamine beta-hydroxylase (DBH), an enzyme involved in the synthesis of neurotransmitters like norepinephrine. This antibody, produced in rabbits, is highly specific to human samples and is validated for use in immunohistochemistry and ELISA applications.DBH is a key enzyme in the biosynthesis of norepinephrine, which plays a crucial role in the central nervous system and the regulation of stress responses. Dysregulation of DBH activity has been implicated in various neurological disorders, making it a target of interest for researchers studying conditions such as depression, anxiety, and schizophrenia.
This antibody binds specifically to the DBH protein, allowing for accurate detection and analysis in a variety of tissue types, including brain tissue. Its high specificity and sensitivity make it an ideal tool for investigating the role of DBH in neurotransmitter synthesis and its potential implications for neurological disorders. Researchers in the fields of neuroscience and psychiatry will find this antibody to be a valuable asset in their studies.
Product Name:
DBH Rabbit Polyclonal Antibody
SKU:
CAB2711
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-200 of human DBH (NP_958852.1).
The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. The encoded protein, expressed in neuroscretory vesicles and chromaffin granules of the adrenal medulla, catalyzes the conversion of dopamine to norepinephrine, which functions as both a hormone and as the main neurotransmitter of the sympathetic nervous system. The enzyme encoded by this gene exists exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. Mutations in this gene cause dopamine beta-hydroxylate deficiency in human patients, characterized by deficits in autonomic and cardiovascular function, including hypotension and ptosis. Polymorphisms in this gene may play a role in a variety of psychiatric disorders.
Purification Method:
Affinity purification
Gene ID:
1621
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of mouse brain, using DBH antibody (CAB2711) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 30s.
