DAZ4 Antibody (PACO13803)
- SKU:
- PACO13803
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
DAZ4 Antibody (PACO13803)
The DAZ4 Antibody (PAC013803) is a polyclonal antibody designed for research involving DAZ4, a gene associated with male fertility. This antibody, produced in rabbits, is highly specific for detecting DAZ4 in human samples and is validated for use in various immunological assays, including Western blotting.DAZ4, a member of the DAZ gene family, is essential for spermatogenesis and male fertility. Mutations in DAZ4 have been linked to male infertility, making it an important target for research in reproductive biology and genetics.
This antibody allows for the detection and analysis of DAZ4 expression in different cell types, providing valuable insights into its function and potential roles in infertility.Understanding the role of DAZ4 in male fertility is crucial for the development of diagnostic tests and potential treatments for infertility related to DAZ4 mutations. This antibody offers researchers a reliable tool for investigating the function of DAZ4 and its implications for reproductive health.
| Antibody Name: | DAZ4 Antibody (PACO13803) |
| Antibody SKU: | PACO13803 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:500-1:5000, IHC:1:5-1:20 |
| Species Reactivity: | Human |
| Immunogen: | Fusion protein of human DAZ4 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO13803(DAZ4 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO13803(DAZ4 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains two copies of the 10.8 kb repeat. Alternatively spliced transcript variants encoding different isoforms have been described. |
| Synonyms: | Deleted in azoospermia protein 4 |
| UniProt Protein Function: | DAZ4: RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation. Defects in DAZ4 may be a cause of spermatogenic failure Y-linked type 2 (SPGFY2). It is a disorder resulting in the absence (azoospermia) or reduction (oligozoospermia) of sperm in the semen, leading to male infertility. AZFc deletions in the Yq11.23 region including the DAZ genes are the most common known genetic cause of human male infertility. Belongs to the RRM DAZ family. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: Yq11.223Disease: Spermatogenic Failure, Y-linked, 2 |
| UniProt Protein Details: | |
| NCBI Summary: | This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains two copies of the 10.8 kb repeat. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Feb 2011] |
| UniProt Code: | Q86SG3 |
| NCBI GenInfo Identifier: | 44887840 |
| NCBI Gene ID: | 57135 |
| NCBI Accession: | Q86SG3.2 |
| UniProt Secondary Accession: | Q86SG3,Q9NR88, Q9NR89 |
| UniProt Related Accession: | Q86SG3 |
| Molecular Weight: | 44,085 Da |
| NCBI Full Name: | Deleted in azoospermia protein 4 |
| NCBI Synonym Full Names: | deleted in azoospermia 4 |
| NCBI Official Symbol: | DAZ4Â Â |
| NCBI Official Synonym Symbols: | pDP1680; pDP1681Â Â |
| NCBI Protein Information: | deleted in azoospermia protein 4 |
| UniProt Protein Name: | Deleted in azoospermia protein 4 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Deleted in azoospermia protein |
| UniProt Gene Name: | DAZ4Â Â |
| UniProt Entry Name: | DAZ4_HUMAN |
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