Daxx Rabbit Polyclonal Antibody (CAB1642)
- SKU:
- CAB1642
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- DAXX
- BING2
- DAP6
- EAP1
Description
Product Name: | Daxx Rabbit Polyclonal Antibody |
SKU: | CAB1642 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 175-400 of human Daxx (NP_001135441.1). |
Sequence: | ASQS PRTR GSRR QIQR LEQL LALY VAEI RRLQ EKEL DLSE LDDP DSAY LQEA RLKR KLIR LFGR LCEL KDCS SLTG RVIE QRIP YRGT RYPE VNRR IERL INKP GPDT FPDY GDVL RAVE KAAA RHSL GLPR QQLQ LMAQ DAFR DVGI RLQE RRHL DLIY NFGC HLTD DYRP GVDP ALSD PVLA RRLR ENRS LAMS RLDE VISK YAML QDKS EEGE RKKR RARL QG |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | DAP6; EAP1; BING2; SMIM40; Daxx |
Positive Sample: | K-562,SH-SY5Y |
Conjugate: | Unconjugated |
Cellular Localization: | Chromosome, Cytoplasm, Nucleus, PML body, centromere, nucleolus, nucleoplasm. |
Calculated MW: | 81kDa |
Observed MW: | 110kDa |
This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 1616 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |