The DAO Monoclonal Antibody is a cutting-edge tool for researchers studying D-amino acid oxidase (DAO), an enzyme with a key role in neurotransmitter metabolism and inflammation regulation. This monoclonal antibody, produced using hybridoma technology, offers superior specificity and sensitivity for detecting DAO in various biological samples.DAO is an essential enzyme involved in the catabolism of D-amino acids, which are increasingly recognized as important modulators of neurotransmission and immune response. Dysregulation of DAO activity has been linked to various neurological disorders, including schizophrenia and Alzheimer's disease, as well as inflammatory conditions such as irritable bowel syndrome.
With its high binding affinity to DAO, this monoclonal antibody enables precise detection and quantification of DAO levels in cell lysates, tissue extracts, and other experimental samples. Its reliability and consistency make it a valuable asset for researchers investigating the molecular mechanisms underlying DAO function and its implications in health and disease.
Product Name:
DAO Monoclonal Antibody
SKU:
CAB22081
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human DAO (NP_001908.3).
This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known; it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia.
Purification Method:
Affinity purification
Gene ID:
1610
Clone Number:
ARC54988
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using DAO antibody (CAB22081) at1:20000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
