| UniProt Protein Function: | DAND5: Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot-containing proteins play important roles during development, organogenesis, tissue growth and differentiation. Belongs to the DAN family.Protein type: Secreted; Cell development/differentiation; Secreted, signal peptideChromosomal Location of Human Ortholog: 19p13.2Cellular Component: extracellular regionMolecular Function: morphogen activityBiological Process: negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of BMP signaling pathway |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8N907 |
| NCBI GenInfo Identifier: | 74729571 |
| NCBI Gene ID: | 199699 |
| NCBI Accession: | Q8N907.1 |
| UniProt Secondary Accession: | Q8N907 |
| UniProt Related Accession: | Q8N907 |
| Molecular Weight: | |
| NCBI Full Name: | DAN domain family member 5 |
| NCBI Synonym Full Names: | DAN domain family member 5, BMP antagonist |
| NCBI Official Symbol: | DAND5Â Â |
| NCBI Official Synonym Symbols: | SP1; CER2; COCO; CRL2; CERL2; DANTE; GREM3; CKTSF1B3Â Â |
| NCBI Protein Information: | DAN domain family member 5; DAN domain family, member 5; cerberus 2; cerberus-like 2; cerberus-like protein 2; cerl-2; cysteine knot superfamily 1, BMP antagonist 3; gremlin-3 |
| UniProt Protein Name: | DAN domain family member 5 |
| UniProt Synonym Protein Names: | Cerberus-like protein 2; Cerl-2; Cysteine knot superfamily 1, BMP antagonist 3; Gremlin-3 |
| Protein Family: | DAN domain family |
| UniProt Gene Name: | DAND5Â Â |
| UniProt Entry Name: | DAND5_HUMAN |
