The DAND5 Polyclonal Antibody (PAC039666) is a valuable tool for researchers studying the role of DAND5 in development and disease. DAND5, also known as Gremlin-1, is a secreted protein that functions as a bone morphogenetic protein (BMP) antagonist, regulating BMP signaling pathways involved in cell differentiation and growth.This polyclonal antibody, produced in rabbits, is highly specific and sensitive for detecting DAND5 in various samples, particularly in Western blot applications. Its ability to bind to DAND5 proteins enables precise detection and analysis, making it an ideal choice for studies in developmental biology, cancer research, and regenerative medicine.
DAND5 has been implicated in diverse biological processes, including embryonic development, tissue regeneration, and tumorigenesis. Its dysregulation has been associated with developmental abnormalities, cancer progression, and other pathologies. By studying the expression and function of DAND5 using this antibody, researchers can gain valuable insights into the molecular mechanisms underlying these processes and explore potential therapeutic targets for various diseases.
Antibody Name:
DAND5 Antibody (PACO39666)
Antibody SKU:
PACO39666
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human DAN domain family member 5 protein (23-189AA)
Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO39666 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO39666 at dilution of 1:100.
Background:
Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot-containing proteins play important roles during development, organogenesis, tissue growth and differentiation (By similarity).
Synonyms:
DAN domain family member 5 (Cerberus-like protein 2) (Cerl-2) (Cysteine knot superfamily 1, BMP antagonist 3) (Gremlin-3), DAND5, CER2 CKTSF1B3 GREM3 SP1
UniProt Protein Function:
DAND5: Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot-containing proteins play important roles during development, organogenesis, tissue growth and differentiation. Belongs to the DAN family.Protein type: Secreted; Cell development/differentiation; Secreted, signal peptideChromosomal Location of Human Ortholog: 19p13.2Cellular Component: extracellular regionMolecular Function: morphogen activityBiological Process: negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of BMP signaling pathway
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry. [provided by RefSeq, Jul 2008]
SP1; CER2; COCO; CRL2; CERL2; DANTE; GREM3; CKTSF1B3Â Â
NCBI Protein Information:
DAN domain family member 5; DAN domain family, member 5; cerberus 2; cerberus-like 2; cerberus-like protein 2; cerl-2; cysteine knot superfamily 1, BMP antagonist 3; gremlin-3
