The Dystroglycan Polyclonal Antibody (CAB10076) is a valuable tool for researchers investigating dystroglycan, a key protein involved in muscle function and development. This antibody, produced in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to dystroglycan, this antibody allows for precise detection and analysis in a variety of cell types, making it an essential component for studies focused on muscle biology, neuromuscular diseases, and developmental disorders.Dystroglycan is a critical component of the dystrophin-glycoprotein complex, which plays a crucial role in maintaining muscle integrity and function. Mutations in genes encoding dystroglycan have been linked to various forms of muscular dystrophy, highlighting the importance of understanding its function and regulation.
Research on dystroglycan not only provides insights into muscle physiology and disease mechanisms but also offers potential targets for therapeutic interventions aimed at treating muscular dystrophies and other muscle-related conditions.Overall, the Dystroglycan Polyclonal Antibody (CAB10076) serves as a valuable tool for researchers interested in uncovering the roles of dystroglycan in muscle biology and disease. Its high reactivity and reliable performance make it an excellent choice for studies seeking to elucidate the molecular mechanisms underlying muscle development, maintenance, and pathology.
Product Name:
DAG1 Rabbit Polyclonal Antibody
SKU:
CAB10076
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 776-895 of human DAG1 (NP_001171108.1).
This gene encodes dystroglycan, a central component of dystrophin-glycoprotein complex that links the extracellular matrix and the cytoskeleton in the skeletal muscle. The encoded preproprotein undergoes O- and N-glycosylation, and proteolytic processing to generate alpha and beta subunits. Certain mutations in this gene are known to cause distinct forms of muscular dystrophy. Alternative splicing results in multiple transcript variants, all encoding the same protein.
Purification Method:
Affinity purification
Gene ID:
1605
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse heart, using DAG1 Rabbit pAb (CAB10076) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
