DAD1 Rabbit Polyclonal Antibody (CAB14723)
- SKU:
- CAB14723
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
Product Name: | DAD1 Rabbit Polyclonal Antibody |
SKU: | CAB14723 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human DAD1 (NP_001335.1). |
Sequence: | MSAS VVSV ISRF LEEY LSST PQRL KLLD AYLL YILL TGAL QFGY CLLV GTFP FNSF LSGF ISCV GSFI LAVC LRIQ INPQ NKAD FQGI SPER AFAD FLFA |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | OST2; DAD1 |
Positive Sample: | A-431,Mouse thymus,Mouse brain,Mouse kidney,Mouse liver,Rat testis |
Conjugate: | Unconjugated |
Cellular Localization: | Endoplasmic reticulum membrane, Multi-pass membrane protein. |
Calculated MW: | 12kDa |
Observed MW: | 22kDa |
DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line. The DAD1 protein disappeared in temperature-sensitive cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggered apoptosis. DAD1 is believed to be a tightly associated subunit of oligosaccharyltransferase both in the intact membrane and in the purified enzyme, thus reflecting the essential nature of N-linked glycosylation in eukaryotes.
Purification Method: | Affinity purification |
Gene ID: | 1603 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |