DAB2 Polyclonal Antibody (CAB3822)
- SKU:
- CAB3822
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- FC
Frequently bought together:
Description
Product Name: | DAB2 Polyclonal Antibody |
SKU: | CAB3822 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 340-580 of human DAB2 (NP_001334.2). |
Sequence: | VDYF GQQF DQIS NRTG KQEA QAGP WPFS SSQT QPAV RTQN GVSE REQN GFSV KSSP NPFV GSPP KGLS IQNG VKQD LESS VQSS PHDS IAII PPPQ STKP GRGR RTAK SSAN DLLA SDIF APPV SEPS GQAS PTGQ PTAL QPNP LDLF KTSA PAPV GPLV GLGG VTVT LPQA GPWN TASL VFNQ SPSM APGA MMGG QPSG FSQP VIFG TSPA VSGW NQPS PFAA STPP PVPV VWGP SASV A |
Tested Applications: | WB FC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 FC,1:20 - 1:50 |
Synonyms: | DOC2; DOC-2; DAB2 |
Positive Sample: | HeLa |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Cytoplasmic vesicle, Membrane, clathrin-coated pit, clathrin-coated vesicle membrane. |
Calculated MW: | 82kDa |
Observed MW: | 96kDa |
This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 1601 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |